Water → HCID 68442821, compound

HRID 1591535Notes

Reaction equation

HRID 1591535 reaction equation
C([O-])(=O)C.[Na+].[CH3:6][C:7]1[O:8][C:9]2[CH:14]=[CH:13][S:12][C:10]=2[N:11]=1.[Br:15]Br.O>C(O)(=O)C>[Br:15][C:13]1[S:12][C:10]2[N:11]=[C:7]([CH3:6])[O:8][C:9]=2[CH:14]=1

Participants

6

Reactant 4

HCID 962WaterHCID 24408BromineHCID 517045Sodium AcetateHCID 138109212-Methylthieno[2,3-d][1,3]oxazole

Product 1

HCID 68442821HCID 68442821, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent2×

Procedure

Sodium acetate (1.4 g) and 2 g of 2-methylthieno[2,3-d]oxazole were dissolved in 24 ml of an acetic acid solvent, and a solution comprised of 15.8 ml of bromine and 7.2 ml of acetic acid was dropwise added thereto with stirring at room temperature. After stirring at room temperature for 2.5 hours, the reaction solution was added to 150 ml of water, followedby further stirring at room temperature for 2 hours. The crystals precipitated were recovered by suction filtration, and dried under reduced pressure, thereby 1.7 g of 5-bromo-2-methylthieno[2,3-d]oxazole was obtained as pale yellow powder (yield: 54%).

Workup

  1. additionwas dropwise added
  2. stirringAfter stirring at room temperature for 2.5 hours
  3. stirringfollowedby further stirring at room temperature for 2 hours
  4. customThe crystals precipitated
  5. filtrationwere recovered by suction filtration
  6. customdried under reduced pressure

Sources & evidence

ORD record
ord-cd5a93f868f64de58fd88cc8111b043c
Source dataset
uspto-grants-2007_11
Patent number
US07291449B2

Reaction notes

Loading…