HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Aminobenzyl alcohol → {4-[4-Chloro-6-(5-chloro-2-methyl-phenyl)-[1,3,5]triazin-2-ylamino]-phenyl}-methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Aminobenzyl alcohol | HCID 69331 | — |
| Reactant | 2,4-Dichloro-6-(5-chloro-2-methyl-phenyl)-[1,3,5]triazine | HCID 85827032 | — |
| Product | {4-[4-Chloro-6-(5-chloro-2-methyl-phenyl)-[1,3,5]triazin-2-ylamino]-phenyl}-methanol | HCID 86588970 | 62% |
Reaction Steps
The reaction of 2,4-dichloro-6-(5-chloro-2-methyl-phenyl)-[1,3,5]triazine and 4-aminobenzyl alcohol using the method described in Example 37 provided the title compound (50 mg, 62% yield). 1H NMR (DMSO-d6) 9.52 (br s, 1H), 7.77 (s, 1H), 7.70 (s, 2H), 7.42 (d, 1H), 7.33 (d, 1H), 7.24 (m, 4H), 5.07 (m, 1H), 4.45 (d, J=5.7 Hz, 2H), 2.52 (s, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07291616B2 |
| Source dataset | uspto-grants-2007_11 |
| ORD ID | ord-6b18fb76683545d79c1c3470613d5094 |
| Source note | uspto-grants-2007_11 |