Hydrochloric Acid → HCID 67131662, compound

Participants

Reaction Steps

1.74 g of methyl 3-[4-(3-{4-[{[(benzyloxy)carbonyl]amino}(imino)methyl]phenoxy}propyl)-2,3-dioxo-1-piperazinyl]propanoate was dissolved in 10 ml of N,N-dimethylformamide. Thereafter, 0.52 g of 5% palladium-carbon suspended in 7.4 ml of N,N-dimethylformamide and 0.85 ml of 6 mol/L hydrochloric acid were added to the solution, followed by stirring under a hydrogen atmosphere at room temperature under atmospheric pressure for 2 hours. After completion of the reaction, the catalyst was removed by filtration, and the residue was washed with 20 ml of N,N-dimethylformamide. The filtrate was then concentrated under a reduced pressure. 20 ml of xylene was added to the obtained residue, and the mixture was further concentrated under a reduced pressure to obtain 1.37 g of methyl 3-[4-(3-{4-[amino(imino)methyl]phenoxy}propyl)-2,3-dioxo-1-piperazinyl]propanoate hydrochloride.

Provenance & Evidence