Water → HCID 67131969, compound

HRID 1591656Notes

Reaction equation

HRID 1591656 reaction equation
[NH2:1][C:2](=[NH:32])[C:3]1[CH:31]=[CH:30][C:6]([O:7][CH2:8][CH2:9][CH2:10][N:11]2[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][CH2:19][O:20][C:21]3[CH:29]=[CH:28][C:24]([C:25]([NH2:27])=[NH:26])=[CH:23][CH:22]=3)[CH2:13][CH2:12]2)=[CH:5][CH:4]=1.C(O)C.[ClH:36].O>C(O)C>[ClH:36].[NH2:27][C:25](=[NH:26])[C:24]1[CH:28]=[CH:29][C:21]([O:20][CH2:19][CH2:18][CH2:17][N:14]2[CH2:15][CH2:16][N:11]([CH2:10][CH2:9][CH2:8][O:7][C:6]3[CH:5]=[CH:4][C:3]([C:2]([NH2:32])=[NH:1])=[CH:31][CH:30]=3)[CH2:12][CH2:13]2)=[CH:22][CH:23]=1

Participants

5

Reactant 3

HCID 962WaterHCID 9803196HCID 9803196, compoundHCID 21887872Ethanol hydrochloride

Product 1

HCID 67131969HCID 67131969, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

0.25 g of 4-{3-[4-(3-{4-[amino(imino)methyl]phenoxy}propyl)-1-piperazinyl]propoxy}benzamidine was suspended in 5.0 ml of ethanol. 1.5 ml of a 2.0 mol/L hydrogen chloride ethanol solution was added to the suspension. Thereafter, 3.0 ml of water was added for dissolution. The solvent was then removed under a reduced pressure. Thereafter, the residue was filtrated with ethanol to obtain 0.25 g of 4-{3-[4-(3-{4-[amino(imino)methyl]phenoxy}propyl)-1-piperazinyl]propoxy}benzamidine hydrochloride.

Workup

  1. customThe solvent was then removed under a reduced pressure
  2. filtrationThereafter, the residue was filtrated with ethanol

Sources & evidence

ORD record
ord-c87e9a0e7218447f9e38586378dad296
Source dataset
uspto-grants-2007_11
Patent number
US07291617B2

Reaction notes

Loading…