HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid → HCID 68811255, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid | HCID 88804 | — |
| Reactant | (3R,4S)-3,4-Difluoropyrrolidine--hydrogen chloride (1/1) | HCID 66880882 | — |
| Product | HCID 68811255 | HCID 68811255 | 67.1% |
Reaction Steps
(4R)-1-(tert-butoxycarbonyl)-4-hydroxy-L-proline (2.31 g, 10 mmol), was coupled with (3R,4S)-rel-3,4-difluoropyrrolidine hydrochloride (1.44 g, 10 mmol, Preparation 4), in a manner analogous to that described in Preparation 1, Step 1, to afford 2.15 g (67%) of the title product as an off-white foam. MS m/z 321 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07291618B2 |
| Source dataset | uspto-grants-2007_11 |
| ORD ID | ord-3114f8fe592048998fff06218d92c0a9 |
| Source note | uspto-grants-2007_11 |