HCID 69423643, compound → HCID 58638700, compound

HRID 1591747Notes

Reaction equation

HRID 1591747 reaction equation
C(OC([CH2:11][NH:12][CH2:13][CH2:14][C:15]1[CH:20]=[CH:19][C:18]([C:21]2[N:22]([C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[CH2:23][CH2:24][N:25]=2)=[CH:17][CH:16]=1)=O)C1C=CC=CC=1>CO.[Pd]>[CH3:11][NH:12][CH2:13][CH2:14][C:15]1[CH:16]=[CH:17][C:18]([C:21]2[N:22]([C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[CH2:23][CH2:24][N:25]=2)=[CH:19][CH:20]=1

Participants

4

Reactant 1

HCID 69423643HCID 69423643, compound

Product 1

HCID 58638700HCID 58638700, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A suspension of 4.0 g (9.14 mmol) of tert.-butyl 2-{4-[2-(benzyl-oxycarbonylmethylamino)ethyl]phenyl}4,5-dihydroimidazole-1-carboxylate and 0.4 g of palladium/10% carbon in 80 ml of methanol was hydrogenated in an autoclave for two hours. The catalyst was then filtered off and the filtrate was evaporated to dryness. The crude product obtained in this manner was immediately reacted further without additional purification.

Workup

  1. filtrationThe catalyst was then filtered off
  2. customthe filtrate was evaporated to dryness

Sources & evidence

ORD record
ord-807b240115434da8aeb5a96d944884f4
Source dataset
uspto-grants-2007_11
Patent number
US07291642B2

Reaction notes

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