Cyclohexanone → HCID 178443965, compound

HRID 1591776Notes

Reaction equation

HRID 1591776 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:8]2[N:9]=[C:10]([CH:13]([NH2:20])[CH2:14][CH2:15][CH2:16][CH:17]([CH3:19])[CH3:18])[NH:11][CH:12]=2)[CH:5]=[CH:6][CH:7]=1.[C:21]1(=O)[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1>>[Br:1][C:2]1[CH:3]=[C:4]([C:8]2[N:9]=[C:10]([CH:13]([NH:20][CH:21]3[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]3)[CH2:14][CH2:15][CH2:16][CH:17]([CH3:18])[CH3:19])[NH:11][CH:12]=2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 7967CyclohexanoneHCID 1784439681-(4-(3-bromophenyl)-1H-imidazol-2-yl)-5-methyl-1-hexanamine

Product 1

HCID 178443965HCID 178443965, compoundYield 38%

Procedure

This compound is obtained according to an operating method similar to that of Stage 35.3 of Example 35 using as starting amine, 1-[4-(3-bromophenyl)-1H-imidazol-2-yl]-5-methyl-1-hexanamine (obtained in Stage 7.3; 0.8 g; 0.0019 mol) and as ketone, cyclohexanone (0.32 ml; 0.0023 mol). A white-coloured powder is obtained with a yield of 38%. Melting point: 236-238° C.

Workup

  1. customThis compound is obtained
  2. customA white-coloured powder is obtained with a yield of 38%

Sources & evidence

ORD record
ord-b572e667fb1f47a3aebea50d1af1c699
Source dataset
uspto-grants-2007_11
Patent number
US07291641B2

Reaction notes

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