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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1591840Generated: October 31, 2026

1-Iodopropane → N-(4-(5-Cyano-1-propyl-1H-pyrrol-2-yl)phenyl)ethanesulfonamide

https://huagongshe.com/reaction/1591840

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-IodopropaneHCID 33643—
ReactantN-[4-(5-Cyano-1H-pyrrol-2-yl)phenyl]ethanesulfonamideHCID 16051191—
ReactantPotassium tert-butoxideHCID 23665647—
ProductN-(4-(5-Cyano-1-propyl-1H-pyrrol-2-yl)phenyl)ethanesulfonamideHCID 160511936.2%

Reaction Steps

N-[4-(5-cyano-1H-pyrrol-2-yl)phenyl]ethanesulfonamide (0.150 g, 0.54 mmol) was alkylated according to the procedure of Example 40 using potassium tert-butoxide (1.08 mL of a 1 M solution, 1.08 mmol) and propyl iodide (0.056 mL, 0.50 mmol) to afford the title compound (0.10 g, 6.2%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07291643B2
Source datasetuspto-grants-2007_11
ORD IDord-7c755063b2d543b5b9163fe583c7aaeb
Source noteuspto-grants-2007_11