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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1591844Generated: October 31, 2026

Benzene, (3-iodopropyl)- → N-{4-[5-cyano-1-(3-phenylpropyl)-1H-pyrrol-2-yl]phenyl}ethanesulfonamide

https://huagongshe.com/reaction/1591844

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzene, (3-iodopropyl)-HCID 138121—
ReactantN-[4-(5-Cyano-1H-pyrrol-2-yl)phenyl]ethanesulfonamideHCID 16051191—
ReactantPotassium tert-butoxideHCID 23665647—
ProductN-{4-[5-cyano-1-(3-phenylpropyl)-1H-pyrrol-2-yl]phenyl}ethanesulfonamideHCID 1605127710%

Reaction Steps

N-[4-(5-cyano-1H-pyrrol-2-yl)phenyl]ethanesulfonamide (0.150 g, 0.54 mmol) was alkylated according to the procedure of Example 40 using potassium tert-butoxide (1.08 mL of a 1 M solution, 1.08 mmol) and 1-Iodo-3-phenylpropane (0.093 mL, 0.60 mmol) to afford the title compound (0.020 g, 10%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07291643B2
Source datasetuspto-grants-2007_11
ORD IDord-bfbb3eb981954de1b449b95335c86d27
Source noteuspto-grants-2007_11