HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluoro-3-nitroaniline → 2,4-difluoro-N-(4-fluoro-3-nitrophenyl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluoro-3-nitroaniline | HCID 67768 | — |
| Reactant | 2,4-Difluorobenzoyl chloride | HCID 588081 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2,4-difluoro-N-(4-fluoro-3-nitrophenyl)benzamide | HCID 9212604 | 84% |
Reaction Steps
Using a method similar to Preparation 13, using 4-fluoro-3-nitroaniline (1.0 g, 6.4 mmol), dioxane (20 mL), and 2,4-difluorobenzoyl chloride (1.46 g, 8.3 mmol) gives the title intertermediate (1.6 g, 84% yield): mass spectrum (ion spray): m/z=297.0 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07291632B2 |
| Source dataset | uspto-grants-2007_11 |
| ORD ID | ord-b508ae27cc934c9096a95eaf571eabde |
| Source note | uspto-grants-2007_11 |