HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2,4-Difluoro-N-(3-amino-4-fluorophenyl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Stannous chloride dihydrate | HCID 61436 | — |
| Reactant | 2,4-difluoro-N-(4-fluoro-3-nitrophenyl)benzamide | HCID 9212604 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2,4-Difluoro-N-(3-amino-4-fluorophenyl)benzamide | HCID 16772647 | 89.2% |
Reaction Steps
Using a method similar to Preparation 14 using 2,4-Difluoro-N-(4-fluoro-3-nitrophenyl)benzamide (Preparation 13) (1.0 g, 3.38 mmol), SnCl2.2H2O (3.8 g, 16.9 mmol), ethanol (25 mL), and concentrated HCl (25 mL), gives the title intermediate (803 mg, 89% yield): mass spectrum (ion spray): m/z=267.0 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07291632B2 |
| Source dataset | uspto-grants-2007_11 |
| ORD ID | ord-6fd2e79dce084d659fc2e4a7c3fb9746 |
| Source note | uspto-grants-2007_11 |