HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,6-Diaminopyridine → N-(6-Aminopyridin-2-yl)-2,6-dichlorobenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,6-Diaminopyridine | HCID 8861 | — |
| Reactant | 2,6-Dichlorobenzoyl chloride | HCID 78392 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | N-(6-Aminopyridin-2-yl)-2,6-dichlorobenzamide | HCID 58997335 | 66.5% |
Reaction Steps
Using a method similar to Preparation 48, using 2,6-diaminopyridine (2.6 g, 24 mmol), dioxane (75 mL), and 2,6-dichlorobenzoyl chloride (1.68 g, 8 mmol)(stir at 25° C. for 16 hr.) gives the title intermediate (1.5 g, 66% yield): mass spectrum (ion spray): m/z=282.0 (M+1)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07291632B2 |
| Source dataset | uspto-grants-2007_11 |
| ORD ID | ord-3db0b532d2914ab1bb3c5155c95d5b65 |
| Source note | uspto-grants-2007_11 |