Cyclohexanecarbonyl chloride → HCID 66938711, compound

HRID 1591912Notes

Reaction equation

HRID 1591912 reaction equation
[CH3:1][N:2]([CH:10]1[CH2:15][CH2:14][N:13]([CH3:16])[CH2:12][CH2:11]1)[C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([NH2:9])[N:4]=1.[CH:17]1([C:23]([Cl:25])=[O:24])[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1>N1C=CC=CC=1>[ClH:25].[CH3:1][N:2]([CH:10]1[CH2:15][CH2:14][N:13]([CH3:16])[CH2:12][CH2:11]1)[C:3]1[N:4]=[C:5]([NH:9][C:23]([CH:17]2[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]2)=[O:24])[CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 75938Cyclohexanecarbonyl chlorideHCID 58997271N-methyl N-(1-methyl-piperidin-4-yl)-pyridine-2,6-diamine

Product 1

HCID 66938711HCID 66938711, compoundYield 88.2%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Prepare according to procedure in Example 69 starting with N-methyl-N-(1-methyl-piperidin-4-yl)-pyridine-2,6-diamine (Preparation 34, 175 mg, 0.794 mmol), cyclohexanecarbonyl chloride (159 μL, 1.19 mmol), and pyridine (15 mL) to yield 257 mg (88%) of the title compound. Mass spectrum (ion spray): m/z 331.2 (M+1); Analysis Calcd for C19H31N4OCl: C, 62.19; H, 8.51; N, 15.27. Found: C, 61.22; H, 8.44; N, 15.39. mp 250–2° C.

Workup

  1. customPrepare

Sources & evidence

ORD record
ord-c815889471ec45158e8b343ad7ed10e7
Source dataset
uspto-grants-2007_11
Patent number
US07291632B2

Reaction notes

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