2,4,6-Trifluorobenzoyl chloride → HCID 66938885, compound

Participants

Reaction Steps

Prepare according to procedure in Example 66 starting with N-methyl-N-(1-methyl-piperidin-4-yl)-pyridine-2,6-diamine (Preparation 34) (200 mg, 0.907 mmol), 2,4,6-trifluorobenzoyl chloride (130 μL, 0.998 mmol), and 1,4-dioxane (10 mL) to yield 302 mg (80%) of the title compound: mass spectrum (ion spray): m/z=379.2 (M+1); Analysis calc'd for C19H22N4OF3Cl.0.5H2O: C, 53.84; H, 5.47; N, 13.22. Found: C, 54.02; H, 5.32; N, 13.56. mp 302° C. (dec.).

Provenance & Evidence