2-(Trifluoromethoxy)benzoyl Chloride → HCID 66938522, compound

Participants

Reaction Steps

Prepare according to procedure in Example 66 starting with N-methyl-N-(1-methyl-piperidin-4-yl)-pyridine-2,6-diamine (Preparation 34) (200 mg, 0.907 mmol), 2-(trifluoromethoxy)benzoyl chloride (175 μL, 1.09 mmol), and 1,4-dioxane (10 mL) to yield 357 mg (88%) of the title compound: mass spectrum (ion spray): m/z=408.8 (M+1); Analysis calc'd for C20H24N4O2F3Cl.1.0H2O: C, 51.89; H, 5.66; N, 12.10. Found: 51.64; 5.50; 12.48. mp 102–4° C.

Provenance & Evidence