HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 10459964, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Sodium Bisulfate | HCID 516919 | — |
| Reactant | Cyclopentylacetyl chloride | HCID 3485182 | — |
| Reactant | 2-(3,5-Bis-trifluoromethyl-benzenesulfonylamino)-4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridin-5-ium hydrochloride | HCID 86608857 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 10459964 | HCID 10459964 | — |
Reaction Steps
DIEA and cyclopentyl-acetyl chloride are added at 0° to a mixture of 75 mg of 2-(3,5-bis-trifluoromethyl-benzenesulfonylamino)-4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridin-5-ium hydrochloride salt in CH2Cl2. The mixture obtained is stirred at RT for 4 hours, 2 ml of 1 M aqueous NaHSO4 solution are added and two phases formed are separated. The organic layer obtained is concentrated and subjected to preparative HPLC (RP-18). N-[5-(2-Cyclo-pentyl-acetyl)-4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridin-2-yl]-3,5-bis-trifluoromethyl-benzene-sulfonamide is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07291734B2 |
| Source dataset | uspto-grants-2007_11 |
| ORD ID | ord-102f2edf65174196aa4fd45899c31a17 |
| Source note | uspto-grants-2007_11 |