Diethyl Ether → 2-(3,5-Bis-trifluoromethyl-benzenesulfonylamino)-4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridin-5-ium hydrochloride

HRID 1591938Notes

Reaction equation

HRID 1591938 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][C:11]2[N:14]=[C:15]([NH:17][S:18]([C:21]3[CH:26]=[C:25]([C:27]([F:30])([F:29])[F:28])[CH:24]=[C:23]([C:31]([F:34])([F:33])[F:32])[CH:22]=3)(=[O:20])=[O:19])[S:16][C:10]=2[CH2:9]1)=O)(C)(C)C.C(OCC)C.C(Cl)[Cl:41]>>[ClH:41].[F:34][C:31]([F:32])([F:33])[C:23]1[CH:22]=[C:21]([S:18]([NH:17][C:15]2[S:16][C:10]3[CH2:9][NH2+:8][CH2:13][CH2:12][C:11]=3[N:14]=2)(=[O:19])=[O:20])[CH:26]=[C:25]([C:27]([F:28])([F:29])[F:30])[CH:24]=1

Participants

4

Reactant 3

HCID 3283Diethyl EtherHCID 6344DichloromethaneHCID 10007211HCID 10007211, compound

Product 1

HCID 866088572-(3,5-Bis-trifluoromethyl-benzenesulfonylamino)-4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridin-5-ium hydrochloride

Procedure

50 ml of saturated etheric hydrochloric add are added to a solution of 9.95 g of 2-(3,5-bis-trifluoromethyl-benzenesulfonylamino)-6,7-dihydro-4H-thiazolo[5,4-c]pyridine-5-carboxylic acid tert-butyl ester in 150 ml of CH2Cl2 and and the mixture obtained is stirred at RT for 4 hours. From the mixture obtained solvent is evaporated and the evaporation residue obtained is treated with diethylether. A solid precipitates, is filtrated off and dried. 2-(3,5-Bis-trifluoromethyl-benzenesulfonylamino)-4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridin-5-ium hydrochloride salt is obtained.

Workup

  1. addition50 ml of saturated etheric hydrochloric add
  2. customthe mixture obtained
  3. customFrom the mixture obtained solvent
  4. customis evaporated
  5. customthe evaporation residue obtained
  6. customA solid precipitates
  7. filtrationis filtrated off
  8. customdried

Sources & evidence

ORD record
ord-505a54d0fd354dd89dbeadaf473ac3dd
Source dataset
uspto-grants-2007_11
Patent number
US07291734B2

Reaction notes

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