thiazole RTI-219 → HCID 69274040, compound

HRID 1591944Notes

Reaction equation

HRID 1591944 reaction equation
S1C=CN=C1.[CH3:6][N:7]1[C@H:11]2[C@@H:12]([C:22]3[S:26][C:25]([C:27]4[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=4)=[CH:24][N:23]=3)[C@@H:13]([C:15]3[CH:16]=[CH:17][C:18]([Cl:21])=[CH:19][CH:20]=3)[CH2:14][C@@H:8]1[CH2:9][CH2:10]2>CO>[ClH:21].[Cl:21][C:18]1[CH:17]=[CH:16][C:15]([C@H:13]2[CH2:14][C@H:8]3[N:7]([CH3:6])[C@H:11]([CH2:10][CH2:9]3)[C@H:12]2[C:22]2[S:26][C:25]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)=[CH:24][N:23]=2)=[CH:20][CH:19]=1

Participants

3

Reactant 1

HCID 86587253thiazole RTI-219

Product 1

HCID 69274040HCID 69274040, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The thiazole was converted into hydrochloride salt: 1H NMR (MeOD) 1.99 (m, 1H), 2.51 (m, 5H), 2.93 (s, 3H), 3.79 (m, 2H), 4.15 (m, 1H), 4.28 (m, 1H), 7.02 (d, J=8.5 Hz, 2H) 7.21 (d, J=8.5 Hz, 2H), 7.39 (m, 5H), 8.06 (s, 1H); mp 228-230° C.; Anal clacd. for C23H24CIN2S.H2O; C, 61.47; H, 5.83; N, 6.23; S, 7.13; Cl, 15.78. Found: C, 61.61; H, 5.76; N, 6.20; S, 7.51; Cl, 15.84; [α]D+27.430 (c, 0.11; CH3OH).

Sources & evidence

ORD record
ord-2896e6c151ab4896be67f3a4e3674159
Source dataset
uspto-grants-2007_11
Patent number
US07291737B2

Reaction notes

Loading…