Methanesulfonic Acid → HCID 9911750, compound

Participants

Reaction Conditions

Reaction Steps

5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione (15 g) in acetone (230 ml) was stirred and heated to reflux for 30 minutes at which point a clear solution was observed. Methanesulfonic acid (4.0 g) was added and the mixture was stirred at reflux for 5 minutes, then cooled to 40° C. and stirred until crystallisation was observed. After cooling to 21° C. the product was collected by filtration and dried under vacuum at 21° C. to provide 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione methanesulfonate (17.3 g) as a white crystalline solid.

Provenance & Evidence