Diethyl Ether → HCID 9911750, compound

Participants

Reaction Conditions

Reaction Steps

Methanesulfonic acid (2.3 ml) was added to a stirred suspension of 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione (12.0 g) in ethanol (100 ml) at 21° C. The reaction mixture was heated to reflux for 30 minutes then cooled to 21° C. Diethyl ether (100 ml) was added and the reaction heated to reflux for 1 hour, then cooled to 21° C. The reaction was heated to reflux, diethyl ether (50 ml) was added and stirred for 30 minutes, cooled to 21° C. over approximately 1 hour, then stirred for 16 hours at 21° C. The product was collected by filtration and dried under vacuum to afford 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione methanesulfonate (14.8 g) as a white crystalline solid.

Provenance & Evidence