Methanesulfonic Acid → HCID 9911750, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl] thiazolidine-2,4-dione (3.0 g) in acetonitrile (60 ml) was heated to 60° C. Methanesulfonic acid (0.54 ml) was added and the mixture stirred at 60° C. to give a clear solution. After cooling to 21° C. the solvent was evaporated under reduced pressure, propan-2-ol (20 ml) added to the residue and the mixture stirred at 21° C. to give a white suspension. The product was collected by filtration, washed with propan-2-ol and dried under vacuum for 5 hours to give 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione methanesulfonate (3.37 g) as a white crystalline solid.

Provenance & Evidence