Methanesulfonic Acid → HCID 9911750, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione (12.0 g) and propan-2-ol (360 ml) was stirred and heated to reflux for 10 minutes at which point a clear solution was observed. Methanesulfonic acid (4.04 ml) was added and the stirred reaction mixture cooled to 75° C., seeded with the product of Example 6 and then cooled to 21° C. over a period of approximately 1 hour. The solid was collected by filtration, washed with propan-2-ol (50 ml) and dried under vacuum for 16 hours to give 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione methanesulfonate (13.8 g) as a white crystalline solid.

Provenance & Evidence