Heptane → HCID 86606005, compound

Participants

Reaction Conditions

Reaction Steps

3.14 g of N-[(1-pyrrolidinyl)methyl]-α-ethyl-2-oxo-1-pyrrolidineacetamide were suspended in 13 ml of methanol. 1.86 g of L-(+)-tartaric acid were added and it was heated at 60° C. 13 ml of heptane were added to the resulting solution, after which it was left to cool to 40° C. It was seeded with a sample of the compound indicated in the example title to start crystallisation. Then it was slowly cooled to 0-5° C. and maintained at this temperature for 4 hours. The crystallised product was separated by filtration and washed twice over the filter with 1 ml of methanol each time, and finally once with 6 ml of hexane. 2.86 g of the compound indicated in the example title was obtained with a diastereoisomeric excess (d.e.): 69% measured by means of HPLC analysis of the free base with a chiral column (Chiralcel OD, hexane/isopropanol, 220 nm).

Provenance & Evidence