Ethyl bromoacetate → HCID 22080505, compound

Participants

Reaction Steps

A solution of 1-aminomethylnaphthalene (2.15 g, 13.6 mmol) and TEA (1.65 g, 16.3 mmol) in CH2Cl2 (50 mL) is treated with ethyl bromoacetate (2.28 g, 13.6 mmol) dropwise over 90 min. The mixture is stirred at RT for 3 h and washed with water. The organic layer is dried over anhydrous MgSO4 and concentrated. The residue is flash chromatographed on silica gel using CH2Cl2→1% MeOH in CH2Cl2 as the eluent to afford N-(1-naphthyl-methyl)-glycine ethyl ester as a yellow oil: [M+1]+=244.

Provenance & Evidence