HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Ethyl-3-nitro PABA → 3-amino-4-ethylamino-benzoic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Ethyl-3-nitro PABA | HCID 3729086 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Oxolane--water (1/1) | HCID 21881883 | — |
| Product | 3-amino-4-ethylamino-benzoic Acid | HCID 854428 | — |
Reaction Steps
A solution of 1.56 g (7.4 mmol) of the title A compound 4-ethylamino-3-nitro-benzoic acid in 60 mL of THF/water (2:1) is hydrogenated at 20 psi over 300 mg of Raney nickel for 18 h. The catalyst is removed by filtration through Celite and the solvent is removed under reduced pressure to give 3-amino-4-ethylamino-benzoic acid as a dark solid. This material is used as such in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07291635B2 |
| Source dataset | uspto-grants-2007_11 |
| ORD ID | ord-6d237297cbed410e884e3be43b602fb6 |
| Source note | uspto-grants-2007_11 |