2-(2,4-Dimethoxy-benzyl)-5-(4-methoxyquinolin-7-ylmethyl)-1,1-dioxo-1,2,5-thiadiazolidin-3-one → 5-(4-Methoxy-quinolin-7-ylmethyl)-1,1-dioxo-1,2,5-thiadiazolidin-3-one

Participants

Reaction Steps

210 mg (459 μmol) of the title D compound, 2-(2,4-dimethoxy-benzyl)-5-(4-methoxy-quinolin-7-ylmethyl)-1,1-dioxo-1,2,5-thiadiazolidin-3-one are stirred for 30 min in 4 mL of 1:1 TFA/CH2Cl2. The solvent is removed on a rotary evaporator and the residue triturated with 4 mL of 1:1 MeCN/water. This mixture is filtered through a 0.2 micron disk and the solvent is removed. The resulting material is purified by preparative LC/MS, and the collected product fractions are lyophilized to give 5-(4-methoxy-quinolin-7-ylmethyl)-1,1-dioxo-1,2,5-thiadiazolidin-3-one: [M−1]−=306.

Provenance & Evidence