反应详情

1.66 g (3.47 mmols) of the title A compound, 4-[5-(2,4-dimethoxy-benzyl)-1,1,4-trioxo-1,2,5-thiadiazolidin-2-ylmethyl]-benzoic acid and 2.5 mL (34 mmol) of SOCl2 in 40 mL toluene are heated at 110° C. until only a small amount of dark solid remained undissolved. The solution is filtered and the solvent is removed on a rotary evaporator and the residual dark purple solid is dried in a vacuum oven overnight to give 4-[5-(2,4-dimethoxy-benzyl)-1,1,4-trioxo-1,2,5-thiadiazolidin-2-ylmethyl]-benzoyl chloride which is used as such without further purification.

1. filtrationThe solution is filtered
2. customthe solvent is removed on a rotary evaporator
3. customthe residual dark purple solid is dried in a vacuum oven overnight