反应详情

400 mg (911 μmol) of the title B compound, 4-[5-(2,4-dimethoxy-benzyl)-1,1,4-trioxo-1,2,5-thiadiazolidin-2-ylmethyl]-benzoyl chloride, 140 μL (1.0 mmol) of TEA and 141 mg (914 μmol) of 4-(methylthio)benzyl alcohol in 10 mL of CH2Cl2 are stirred at RT for 18 h. The solvent is removed under reduced pressure and the residue is chromatographed on a Biotage 40M column with 98/2 —CH2Cl2/EtOAc to give 4-[5-(2,4-dimethoxy-benzyl)-1,1,4-trioxo-1,2,5-thiadiazolidin-2-ylmethyl]-benzoic acid 4-methylsulfanyl-benzyl ester: [M+NH4]+=574.

1. customThe solvent is removed under reduced pressure
2. customthe residue is chromatographed on a Biotage 40M column with 98/2 —CH2Cl2/EtOAc