HCID 67139624, compound → HCID 10194917, compound

Participants

Reaction Steps

90 mg (150 μmol) of the title D compound, 4-[5-(2,4-dimethoxy-benzyl)-1,1,4-trioxo-1,2,5-thiadiazolidin-2-ylmethyl]-benzoic acid 4-methanesulfonyl-benzyl ester are stirred in 4 mL of 1:1—TFA:CH2Cl2 for 50 min. The solvent is removed and the residue triturated with 4 mL of 1:1—MeCN:H2O. This mixture is filtered through a 0.2μ disk and the solvent is removed. The resulting material is purified by LC/MS and afforded 4-(1,1,4-trioxo-1,2,5-thiadiazolidin-2-ylmethyl)-benzoic acid 4-methanesulfonyl-benzyl ester: 1H-NMR (DMSO-d6) δ 3.22 (3H, s), 3.71 (2H, s), 4.27 (2H, s), 5.48 (2H, s), 7.54 (2H, d, J=8.1), 7.74 (2H, d, J=8.1), 7.96 (2H, d, J=8.5), 8.01 (2H, J=8.5); [M−1]−=437.

Provenance & Evidence