N-Acetyl-L-phenylalanine → HCID 67139620, compound

Participants

Reaction Steps

HOBt (19 mg, 0.125 mmol), (S)-2-acetylamino-3-phenyl-propionic acid (26 mg, 0.125 mmol) and EDCl (26 mg, 0.138 mmol) are added to a solution of the title G compound, (S)-2-amino-3-{3-[5-(4-methoxy-benzyl)-1,1,4-trioxo-1,2,5-thiadiazolidin-2-ylmethyl]-phenyl}-N-pentylpropionamide (63 mg, 0.125 mmol) in CH2Cl2 (4 mL) at RT. After 30 min, the reaction is concentrated. The product is taken up in EtOAc, washed with 1N aqueous HCl, saturated aqueous NaHCO3 and brine. The organic solution is dried over anhydrous MgSO4 and concentrated to yield (S)-2-((S)-2-acetylamino-3-phenyl-propionylamino)-3-{3-[5-(4-methoxy-benzyl)-1,1,4-trioxo-1,2,5-thiadiazolidin-2-ylmethyl]-phenyl}-N-pentyl-propionamide as a white foam: [M+1]+=692.

Provenance & Evidence