Trifluoroacetic acid → HCID 58997405, compound

Participants

Reaction Steps

A solution of the title E compound, 5-[5-(2,4-dimethoxy-benzyl)-1,1,4-trioxo-1,2,5-thiadiazolidin-2-ylmethyl]-thiophene-2-carboxylic acid methyl-phenethyl-amide (70 mg, 0.13 mmol) in CH2Cl2 (2 mL) is stirred with TFA (2 mL) at RT for 4 h. The volatiles are evaporated and the residue is stirred in equal volumes of MeCN/water (4 mL). The mixture is filtered through a 0.2μ Acrodisc and the solvents are evaporated to dryness. The residue is trituated from Et2O to afford 5-(1,1,4-trioxo-1,2,5-thiadiazolidin-2-ylmethyl)-thiophene-2-carboxylic acid methyl-phenethylamide as an off white solid: [M−1]−=392.

Provenance & Evidence