Methyl morpholine oxide → HCID 67138236, compound

Participants

Reaction Steps

The title C compound, 2-(2,4-dimethoxy-benzyl)-5-[5-(1-hydroxy-4-methyl-pentyl)-thiophen-2-ylmethyl]-1,1-dioxo-1,2,5-thiadiazolidin-3-one (125 mg, 0.26 mmol) is dissolved in THF (10 mL) and 4-methylmorpholine N-oxide (152 mg, 1.3 mmol) is added. Tetrapropylammonium perruthenate (TPAP, 9 mg, 0.026 mmol) is added and the mixture is stirred at RT for 1 h. The mixture is filtered through Celite and diluted with EtOAc. The solution is washed with 1N aqueous HCl and the organic layer is dried over anhydrous MgSO4. The solvent is evaporated to afford 2-(2,4-dimethoxy-benzyl)-5-[5-(4-methyl-pentanoyl)-thiophen-2-ylmethyl]-1,1-dioxo-1,2,5-thiadiazolidin-3-one as a clear oil.

Provenance & Evidence