Methanol → Methyl 2-(2-nitrophenyl)acetate

HRID 1592017Notes

Reaction equation

HRID 1592017 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH2:10][C:11]([OH:13])=[O:12])([O-:3])=[O:2].[CH3:14]O>>[CH3:14][O:12][C:11](=[O:13])[CH2:10][C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=1[N+:1]([O-:3])=[O:2]

Participants

3

Reactant 2

HCID 887MethanolHCID 77337(2-Nitrophenyl)acetic acid

Product 1

HCID 520464Methyl 2-(2-nitrophenyl)acetate

Procedure

(2-Nitro-phenyl)-acetic acid (10.93 g, 60.3 mmol) is dissolved in MeOH (200 mL) and HCl gas is bubbled through the solution for 10 min. The reaction is stirred capped for 18 h, then concentrated under reduced pressure to yield (2-nitro-phenyl)-acetic acid methyl ester as a yellow oil.

Workup

  1. customHCl gas is bubbled through the solution for 10 min
  2. customcapped for 18 h
  3. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-a920ae4c1b194d0f98ce1dbd3b7f1bd0
Source dataset
uspto-grants-2007_11
Patent number
US07291635B2

Reaction notes

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