HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(t-butoxycarbonyl-sulfamoyl)-N-[2-(methoxycarbonylmethyl)-phenyl]-glycine t-butyl ester → N-sulfamoyl-N-[2-(methoxycarbonylmethyl)-phenyl]glycine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(t-butoxycarbonyl-sulfamoyl)-N-[2-(methoxycarbonylmethyl)-phenyl]-glycine t-butyl ester | HCID 67138370 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | N-sulfamoyl-N-[2-(methoxycarbonylmethyl)-phenyl]glycine | HCID 67138346 | — |
Reaction Steps
The title D compound, N-(t-butoxycarbonyl-sulfamoyl)-N-[2-(methoxycarbonyl-methyl)-phenyl]-glycine t-butyl ester (1.87 g, 4.07 mmol) is dissolved in a mixture of TFA (35 mL) and CH2Cl2 (35 mL) and stirred for 30 min. The reaction is concentrated in vacuo, then triturated with diethyl ether to yield N-sulfamoyl-N-[2-(methoxycarbonylmethyl)-phenyl]glycine as a clear glass.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07291635B2 |
| Source dataset | uspto-grants-2007_11 |
| ORD ID | ord-27fa49cb78b84887b32bc4d9df79f8c9 |
| Source note | uspto-grants-2007_11 |