HCID 67138409, compound → HCID 67139914, compound

Participants

Reaction Steps

A solution of the title F compound, 3-(3-benzyloxy-4-nitro-phenyl)-2-t-butyloxycarbonylamino-propionic acid methyl ester (733 mg, 1.7 mmol) in a mixture of CH2Cl2-trifluoroacetic acid (1:1, 7 mL) is stirred at RT for 30 min, then evaporated. The residue is partitioned between EtOAc and saturated aqueous NaHCO3. The layers are separated and the aqueous layer is extracted once more with EtOAc. The combined organic extracts are washed with brine, dried over anhydrous MgSO4, filtered and evaporated to give 3-(3-benzyloxy-4-nitro-phenyl)-2-amino-propionic acid methyl ester as a viscous yellow oil.

Provenance & Evidence