HCID 67140010, compound → HCID 67139744, compound

HRID 1592038Notes

Reaction equation

HRID 1592038 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:26]=[CH:27][C:28]=1[N+:29]([O-])=O)[CH2:12][CH:13]1[NH:19][C:18](=[O:20])[C:17]2[CH:21]=[CH:22][CH:23]=[CH:24][C:16]=2[NH:15][C:14]1=[O:25])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CCOC(C)=O.CO.[Pt]=O>[NH2:29][C:28]1[CH:27]=[CH:26][C:11]([CH2:12][CH:13]2[NH:19][C:18](=[O:20])[C:17]3[CH:21]=[CH:22][CH:23]=[CH:24][C:16]=3[NH:15][C:14]2=[O:25])=[CH:10][C:9]=1[O:8][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 67140010HCID 67140010, compound

Product 1

HCID 67139744HCID 67139744, compound

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 21584119Ethylacetate methanolSolvent

Procedure

A solution of the title J compound, 3-(3-benzyloxy-4-nitro-benzyl)-3,4-dihydro-1H-benzo[1,4]diazepine-2,5-dione (196 mg, 0.47 mmol) in EtOAc-methanol (1:1, 44 mL) is hydrogenated over platinum oxide (22 mg) at atmospheric pressure for 1 h. The catalyst is filtered off and the filtrate is evaporated to dryness to give 3-(4-amino-3-benzyloxy-benzyl)-3,4-dihydro-1H-benzo[1,4]diazepine-2,5-dione as a foam: [M+1]+=388.

Workup

  1. filtrationThe catalyst is filtered off
  2. customthe filtrate is evaporated to dryness

Sources & evidence

ORD record
ord-543cec31bda14780897034d859ae5116
Source dataset
uspto-grants-2007_11
Patent number
US07291635B2

Reaction notes

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