Trifluoroacetic acid → HCID 67138785, compound

Participants

Reaction Steps

A solution of the title A compond, ((S)-2-(4-[5-{4-methoxy-benzyl)-1,1,4-trioxo-1,2,5-thiadiazolidin-2-yl]-phenyl}-1-pentylcarbamoyl-ethyl)-carbamic acid t-butyl ester (64 mg, 0.108 mmol) in CH2Cl2 (1 mL) is treated with TFA (1 mL). After 20 min, the solvent is evaporated under stream of nitrogen. The residue is partitioned between EtOAc and saturated aqueous NaHCO3, and the organic solution is washed with brine, dried over anhydrous MgSO4, filtered and concentrated to yield (S)-2-amino-3-{4-[5-(4-methoxy-benzyl)-1,1,4-trioxo-1,2,5-thiadiazolidin-2-yl]-phenyl}-N-pentyl-propionamide as a white solid: [M+1]+=489.

Provenance & Evidence