N-Acetyl-L-phenylalanine → HCID 67139939, compound

Participants

Reaction Steps

HOBt (16 mg, 0.102 mmol), (S)-2-acetylamino-3-phenyl-propionic acid (21 mg, 0.102 mmol) and EDCl (21 mg, 0.112 mmol) are added to a solution of the title B compound, (S)-2-amino-3-{4-[5-(4-methoxy-benzyl)-1,1,4-trioxo-1,2,5-thiadiazolidin-2-yl]-phenyl}-N-pentyl-propionamide (50 mg, 0.102 mmol) in CH2Cl2 (3 mL) and the reaction is stirred at RT for 2.5 h, then concentrated. The residue is taken up in EtOAc, washed with 1N aqueous HCl, saturated NaHCO3 and brine, dried over anhydrous MgSO4, filtered and concentrated to yield (S)-2-acetylamino-N-((S)-2-{4-[5-(4-methoxy-benzyl)-1,1,4-trioxo-1,2,5-thiadiazolidin-2-yl]-phenyl}-1-pentylcarbamoyl-ethyl)-3-phenyl-propionamide as a white foam: [M+1]+=678.

Provenance & Evidence