N-Acetyl-L-phenylalanine → HCID 67139666, compound

Participants

Reaction Steps

HOBt (40.5 mg, 0.264 mmol), (S)-2-acetylamino-3-phenyl-propionic acid (54.7 mg, 0.264 mmol) and EDCl (50.6 mg, 0.264 mmol) are added to a solution of the title G compound, (S)-2-amino-3-{3-[5-(4-methoxy-benzyl)-1,1,4-trioxo-1,2,5-thiadiazolidin-2-yl]-phenyl}-N-pentyl-propionamide (129 mg, 0.264 mmol) in CH2Cl2 (5 mL) and stirred at RT for 2 h. The reaction is concentrated and the product is taken up in EtOAc, washed with 1N aqueous HCl, saturated aqueous NaHCO3 and brine, dried over magnesium sulfate, filtered and concentrated to yield (S)-2-acetylamino-N-((S)-2-{3-[5-(4-methoxy-benzyl)-1,1,4-trioxo-1,2,5-thiadiazolidin-2-yl]-phenyl}-1-pentylcarbamoyl-ethyl)-3-phenyl-propionamide as a white solid: [M+1]+=678.

Provenance & Evidence