Formamide → HCID 11244825, compound

Participants

Reaction Steps

The above nitrile (316 mg, 1.0 mmol) and formamide (3 μL) were heated in a SmithSynthesizer™ (Personal Chemistry) at 150° C. for 16 h. The reaction mixture was poured into water and the resulting solid was collected by filtration. The solid was further purified with HPLC (Shimadzu, Thermohypersil PEP 100-C18, 254 nM, acetonitrile/water 15-70% in 25 minutes, retention time=12.61 min) to give the title compound as a white solid (120 mg, 35%).

Provenance & Evidence