Acetic Acid → HCID 11214431, compound

Participants

Reaction Steps

The above amino alcohol (200 mg, 0.586 mmol) and 1-(4-amino-9-propyl -pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-7-yl)-piperidin-4-one (Example 4) (200 mg, 0.894 mmol) was dissolved in 10 mL of dry DMF. MP-Cyanoborohydride (375 mg, 0.884 mmol) was added followed by glacial acetic acid (0.3 mL). This mixture was shaken for 16 h. The resin was removed by filtration and washed with MeOH and dichloromethane. The filtrate was evaporated. The residue was treated with 2 M sodium carbonate solution. The resulting solid was collected by filtration and recrystalized from MeOH/acetonitrile to give the title compound as a pale-colored solid. Yield: 189 mg, 63%.

Provenance & Evidence