Hydrochloric Acid → HCID 58997596, compound

Participants

Reaction Steps

3-Amino-6-(4-hydroxy-piperidin-1-yl)-4-propyl-thieno[2,3-b]pyridine-2-carbonitrile (316 mg, 1.00 mmol) (see Example 2) was dissolved in 3 mL of HCl in EtOH (1.25 M). To this solution at 0° C. was added isoamyl nitrite (0.42 mL, 3.0 mmol). The reaction mixture was warmed up to room temperature in 2 h. The resulting precipitate was collected by filtration and washed with MeOH to give 1-(4-chloro-9-propyl-pyrido[3′,2′:4,5]thieno[3,2-d][1,2,3]triazin-7-yl)-piperidin-4-ol as a yellow solid (120 mg, 35%).

Provenance & Evidence