反应详情

To 2 ml of ethanol were added 0.3 g of 4,5,6-trichloropyrimidine and 0.5 g of N-ethylaniline, followed by heating under reflux for 8 hours. The reaction mixture was then left for cooling to room temperature and concentrated under reduced pressure. The residue was added water and extracted three times with t-butyl methyl ether. The organic layers were combined, dried over anhydrous magnesium sulfate, and then concentrated. The residue was subjected to silica gel column chromatography to give 0.5 g of 4,5-dichloro-6-(N-ethyl-N-phenylamino)pyrimidine.

1. temperatureby heating
2. temperatureunder reflux for 8 hours
3. waitThe reaction mixture was then left
4. concentrationconcentrated under reduced pressure
5. additionThe residue was added water
6. extractionextracted three times with t-butyl methyl ether
7. dry with materialdried over anhydrous magnesium sulfate
8. concentrationconcentrated