Hydroxyamine hydrochloride → 6-fluoro-3,4-dihydronaphthalen-2(1H)-one Oxime

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Reaction Steps

A solution of 6-fluoro-3,4-dihydronaphthalen-2(1H)-one (W. Adcock, P. D. Bettess, S. Q. A. Rizvi, Aust. J. Chem. 1970, 23, 1921-1937; 1.50 g, 9.13 mmol) in ethanol (10 mL) was treated with hydroxylamine hydrochloride (775 mg, 11.14 mmol), sodium acetate (2.01 g, 14.79 mmol) and water (6 mL) and the mixture was stirred at room temperature for 30 min, during which time a dense precipitate formed. The mixture was diluted with water and extracted with ether. The organic phases were dried and concentrated to provide a yellowish solid (1.58 g, 97%) used without further purification.

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