HuagongsheHuagongshe Chemistry Print Report · For research reference only
Propylamine → 3-(4-Fluorophenyl)-N-propylpropan-1-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Propylamine | HCID 7852 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | 3-(4-Fluorophenyl)propanal | HCID 10197782 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-(4-Fluorophenyl)-N-propylpropan-1-amine | HCID 46906452 | — |
Reaction Steps
A solution of the crude 3-(4-fluorophenyl)propanal and propylamine (3.0 g, 51 mmol) in CH2Cl2 and was treated with NaBH(OAc)3 and stirred at room temperature overnight. The reaction was quenched with 1 N NaOH, and washed successively with water and brine. The solvent was evaporated under vacuum to give 4.3 g of 3-(4-fluorophenyl)-N-propylpropan-1-amine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07291744B2 |
| Source dataset | uspto-grants-2007_11 |
| ORD ID | ord-290aa98cebed4ffe9d3b01e063a88153 |
| Source note | uspto-grants-2007_11 |