HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → 3-(4-Fluorophenyl)propionyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3-(4-Fluorophenyl)propionic acid | HCID 136302 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-(4-Fluorophenyl)propionyl chloride | HCID 21964258 | 86.8% |
Reaction Steps
3-(para-Fluorophenyl)propionic acid (25.00 g, 150.0 mmol, 1 eq.) was dissolved in methylene chloride (100 mL) at 25° C. under N2 and thionyl chloride (54.2 mL, 740.0 mmol, 5 eq.) added dropwise via an addition funnel. Worked up after 24 hours by stripping off the solvent then rerotovaping 2 times from toluene (25 mL) to obtain 24.3 g of a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07291744B2 |
| Source dataset | uspto-grants-2007_11 |
| ORD ID | ord-85272490bfd14b97a424579e5dc9d4dc |
| Source note | uspto-grants-2007_11 |