Trifluoroacetic anhydride → HCID 67272592, compound

Participants

Reaction Steps

To a solution of 2,3-dimethyl-5-trifluoromethyl-pyridine 1-oxide (0.620 g, 3.24 mmol) in CH2Cl2 (20 mL) was added TFAA (1.36 g, 6.48 mmol) at room temperature. After the mixture was stirred at room temperature for 3 h, brine (5 mL) and K2CO3 (20 mL) were added. The mixture was stirred at room temperature for 1 h and then extracted with CH2Cl2 (3×20 mL). The extracts were combined and dried over Na2SO4. After filtration the solvent was removed, and the residue was purified on silica gel column (4:1, CH2Cl2/Et2O), affording (2,3-dimethyl-5-trifluoromethyl-pyridin-2-yl)-methanol as a pale yellow oil (0.300 g, 48%).

Provenance & Evidence