HuagongsheHuagongshe Chemistry Print Report · For research reference only
m-Chloroperbenzoic acid → 5-Fluoro-2,3-dimethyl-1-oxidopyridin-1-ium
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | m-Chloroperbenzoic acid | HCID 70297 | — |
| Reactant | 5-Fluoro-2,3-dimethylpyridine | HCID 45079981 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-Fluoro-2,3-dimethyl-1-oxidopyridin-1-ium | HCID 19791232 | — |
Reaction Steps
A mixture of 3-fluoro-5,6-dimethyl-pyridine (0.230 g, 1.84 mmol) (Ife, R. J. Eur. Pat. Appl. (1987), EP 246774), 3-chloroperoxybenzoic acid (77%, 1.24 g, 5.5 mmol) in CH2Cl2 (25 mL) was stirred for 16 h. The solution was concentrated, and the residue was purified by flash chromatography on a silica gel column (8:1 EtOAc/MeOH), affording 3-fluoro-5,6-dimethyl-pyridine-1-oxide as a white solid (0.225 g 87%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07291631B2 |
| Source dataset | uspto-grants-2007_11 |
| ORD ID | ord-26725b8ee86f4a00b05015fc9d56a312 |
| Source note | uspto-grants-2007_11 |