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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1592525Generated: October 30, 2026

1-(Pyridin-2-yl)ethan-1-amine → N-((3-Methylpyridin-2-yl)methyl)-1-(pyridin-2-yl)ethanamine

https://huagongshe.com/reaction/1592525

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(Pyridin-2-yl)ethan-1-amineHCID 541877—
Reactant3-Methylpyridine-2-carboxaldehydeHCID 1501874—
ReactantSodium borohydrideHCID 4311764—
SolventMethanolHCID 887—
ProductN-((3-Methylpyridin-2-yl)methyl)-1-(pyridin-2-yl)ethanamineHCID 4509800960%

Reaction Steps

Using General Procedure B, reaction of 1-Pyridin-2-yl-ethylamine and 3-methylpyridine-2-carbaldehyde in MeOH with NaBH4 gave (3-Methyl-pyridin-2-ylmethyl)-(1-pyridin-2-ylethyl)-amine as a pale yellow oil (0.21 g, 60%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07291631B2
Source datasetuspto-grants-2007_11
ORD IDord-25c2fe2419b74e2aab1d87f5b7d60b7f
Source noteuspto-grants-2007_11