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tert-Butyl 4-oxopiperidine-1-carboxylate → 4-[(3,5-Dimethyl-pyridin-2-ylmethyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | tert-Butyl 4-oxopiperidine-1-carboxylate | HCID 735900 | — |
| 反応物 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 反応物 | (3,5-Dimethylpyridin-2-yl)methanamine | HCID 18507412 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4-[(3,5-Dimethyl-pyridin-2-ylmethyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester | HCID 67271627 | — |
反応手順
Using General Procedure B, reaction of N-Boc-4-piperidone, C-(3,5-dimethylpyridin-2-yl)-methylamine and NaBH(OAc)3 in CH2Cl2 gave 4-[(3,5-dimethyl-pyridin-2-ylmethyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07291631B2 |
| 出典データセット | uspto-grants-2007_11 |
| ORD ID | ord-e472c2c7e0f641ee812ebebee861bd4e |
| 出典メモ | uspto-grants-2007_11 |